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Literature summary extracted from

  • Brower, C.S.; Varshavsky, A.
    Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations (2009), PLoS ONE, 4, e7757.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.8 mouse genomic DNA encoding Ate1 is isolated from a BAC library, Ate1-deficient mouse strains are constructed Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.8 60000
-
 determined by SDS-PAGE and Western Blot analysis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.8 L-arginyl-tRNAArg + protein Mus musculus
-
 tRNAArg + L-arginyl-[protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.8 Mus musculus Q9Z2A5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.8 brain
-
 Mus musculus
-
2.3.2.8 brown adipose tissue
-
 Mus musculus
-
2.3.2.8 heart
-
 Mus musculus
-
2.3.2.8 kidney
-
 Mus musculus
-
2.3.2.8 liver
-
 Mus musculus
-
2.3.2.8 muscle
-
 Mus musculus
-
2.3.2.8 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.8 L-arginyl-tRNAArg + protein
-
 Mus musculus tRNAArg + L-arginyl-[protein]
-
 ?
2.3.2.8 L-arginyl-tRNAArg + Rgs16 regulator of G protein
-
 Mus musculus tRNAArg + L-arginyl-[Rgs16 regulator of G protein]
-
 ?
2.3.2.8 L-arginyl-tRNAArg + Rgs4 regulator of G protein
-
 Mus musculus tRNAArg + L-arginyl-[Rgs4 regulator of G protein]
-
 ?
2.3.2.8 L-arginyl-tRNAArg + Rgs5 regulator of G protein
-
 Mus musculus tRNAArg + L-arginyl-[Rgs5 regulator of G protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.8 Arg-tRNA-protein transferase
-
 Mus musculus
2.3.2.8 arginyl-tRNA-protein transferase 1
-
 Mus musculus
2.3.2.8 arginyltransferase
-
 Mus musculus
2.3.2.8 Ate1
-
 Mus musculus
2.3.2.8 R-transferase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.2.8 physiological function N-terminal arginylation of intracellular proteins by Arg-tRNA-protein transferase is a part of the N-end rule pathway of protein degradation Mus musculus