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Literature summary extracted from

  • Guenther, S.; Matuschewski, K.; Mueller, S.
    Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival (2009), PLoS ONE, 4, e5510.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
6.3.1.20 additional information knockout of Plasmodium falciparum LplA1 failed because the protein is essential for growth of parasite Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.1.20 apicoplast
-
 Plasmodium falciparum 20011
-
6.3.1.20 apicoplast
-
 Plasmodium berghei 20011
-
6.3.1.20 mitochondrion
-
 Plasmodium falciparum 5739
-
6.3.1.20 mitochondrion
-
 Plasmodium berghei 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.1.20 45000
-
 SDS-PAGE Plasmodium falciparum
6.3.1.20 45000
-
 SDS-PAGE Plasmodium berghei

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.181 Plasmodium falciparum
-
-
-
6.3.1.20 Plasmodium berghei
-
-
-
6.3.1.20 Plasmodium falciparum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.20 ATP + D-lipoic acid
-
 Plasmodium falciparum diphosphate + D-lipoyl-AMP
-
 ?
6.3.1.20 ATP + D-lipoic acid
-
 Plasmodium berghei diphosphate + D-lipoyl-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.181 LipB
-
 Plasmodium falciparum
2.3.1.181 octanoyl (lipoyl): N-octanoyl (lipoyl) transferase
-
 Plasmodium falciparum
6.3.1.20 lipoic acid protein ligase
-
 Plasmodium falciparum
6.3.1.20 lipoic acid protein ligase
-
 Plasmodium berghei
6.3.1.20 lipoic acid protein ligase A1
-
 Plasmodium falciparum
6.3.1.20 lipoic acid protein ligase A1
-
 Plasmodium berghei
6.3.1.20 LplA1
-
 Plasmodium falciparum
6.3.1.20 LplA1
-
 Plasmodium berghei
6.3.1.20 Lpla2
-
 Plasmodium falciparum
6.3.1.20 Lpla2
-
 Plasmodium berghei

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.1.20 ATP
-
 Plasmodium falciparum
6.3.1.20 ATP
-
 Plasmodium berghei

General Information

EC Number General Information Comment Organism
2.3.1.181 metabolism The apicoplast-specific LipB is dispensable for parasite growth due to functional redundancy of the parasite’s lipoic acid/octanoic acid ligases/transferases. Plasmodium falciparum
6.3.1.20 malfunction LplA1 knockout cannot be achieved because of the essential function of the gene/protein in asexual parasite growth Plasmodium berghei
6.3.1.20 metabolism LplA1 plays a critical role for asexual parasite growth in vitro and in vivo. Plasmodium berghei
6.3.1.20 metabolism LplA1 plays a pivotal role during the development of the erythrocytic stages of the malaria parasite. Plasmodium falciparum
6.3.1.20 physiological function LplA1 plays a pivotal role during the development of the erythrocytic stages (asexual parasite growth) of Plasmodium falciparum Plasmodium falciparum