Literature summary extracted from
Solinger, J.A.; Paolinelli, R.; Kloess, H.; Scorza, F.B.; Marchesi, S.; Sauder, U.; Mitsushima, D.; Capuani, F.; Stuerzenbaum, S.R.; Cassata, G.
The Caenorhabditis elegans elongator complex regulates neuronal alpha-tubulin acetylation (2010), PLoS Genet., 6, e1000820.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
2.3.1.108 |
additional information |
in an mec-12(e1607) background, i.e. a putative null mutant, acetylation of microtubules is absent in all developmental stages |
Caenorhabditis elegans |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.3.1.108 |
Caenorhabditis elegans |
- |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.3.1.108 |
elongator |
- |
Caenorhabditis elegans |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.3.1.108 |
physiological function |
elongator, a GTPase component of the hyperphosphorylated holoenzyme RNA polymerase II, is a regulator of alpha-tubulin acetylation in vivo. Elongator is important for microtubule function in correct loading and velocity of vesicles in vivo, and acetylation has a function in fine-tuning intrinsic dynamics of microtubules by modulating alpha-tubulin turnover |
Caenorhabditis elegans |