Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Barua, D.; Faeder, J.R.; Haugh, J.M.
    A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases (2009), PLoS Comput. Biol., 5, e1000364.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information SH2-Bb and dimerized receptors synergistically promote Jak2 trans-activation in the context of intracellular signaling, SH2-B and receptor dimers constitute a bipolar clamp that stabilizes the active configuration of two Jak2 molecules in the same macro-complex Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein Jak2 can be phosphorylated on Y1 and Y2 only when two Jak2 molecules are associated with the same complex (receptor or/and SH2-Bbeta mediated). Once Y2 is phosphorylated, the catalytic efficiency of that Jak2 molecule increases substantially Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 JAK2
-
 Homo sapiens
2.7.10.2 Janus kinase
-
 Homo sapiens
2.7.10.2 non-receptor protein tyrosine kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
 Homo sapiens