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Literature summary extracted from

  • Monreal, J.; McLoughlin, F.; Echevarría, C.; García-Mauriño, S.; Testerink, C.
    Phosphoenolpyruvate carboxylase from C4 leaves is selectively targeted for inhibition by anionic phospholipids (2010), Plant Physiol., 152, 634-638.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.31 lyso-phosphatidic acid addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 45% of the control activity Sorghum bicolor
4.1.1.31 lyso-phosphatidic acid addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 45% of the control activity Zea mays
4.1.1.31 additional information not inhibited by phosphatidic acid, phosphatidylinositol, phosphatidylinositol 4-phosphate, lyso-phosphatidic acid, phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine Arabidopsis thaliana
4.1.1.31 additional information phosphatidylcholine and phosphatidylethanolamine have no effect on enzyme activity Sorghum bicolor
4.1.1.31 additional information phosphatidylcholine and phosphatidylethanolamine have no effect on enzyme activity Zea mays
4.1.1.31 phosphatidic acid addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity. Inclusion of D-glucose 6-phosphate or L-malate do not change the effect of phosphatidic acid on PEPC, preincubation of the enzyme with 5 mM phosphoenolpyruvate prior to the addition of phosphatidic acid did not prevent inactivation either. The incubation of phosphatidic acid-inactivated PEPC with protein kinase A does not restore PEPC activity Sorghum bicolor
4.1.1.31 phosphatidic acid addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity. Inclusion of D-glucose 6-phosphate or L-malate do not change the effect of phosphatidic acid on PEPC, preincubation of the enzyme with 5 mM phosphoenolpyruvate prior to the addition of phosphatidic acid did not prevent inactivation either. The incubation of phosphatidic acid-inactivated PEPC with protein kinase A does not restore PEPC activity Zea mays
4.1.1.31 phosphatidylinositol addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity Sorghum bicolor
4.1.1.31 phosphatidylinositol addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 40% of the control activity Zea mays
4.1.1.31 phosphatidylinositol 4-phosphate addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 50% of the control activity Sorghum bicolor
4.1.1.31 phosphatidylinositol 4-phosphate addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 50% of the control activity Zea mays
4.1.1.31 phosphatidylserine addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 80% of the control activity Sorghum bicolor
4.1.1.31 phosphatidylserine addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 80% of the control activity Zea mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.31 membrane the enzyme partially localizes to membranes Zea mays 16020
-
4.1.1.31 membrane the enzyme partially localizes to membranes Arabidopsis thaliana 16020
-
4.1.1.31 membrane the enzyme partially localizes to membranes Sorghum bicolor 16020
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.31 Arabidopsis thaliana
-
-
-
4.1.1.31 Sorghum bicolor
-
-
-
4.1.1.31 Zea mays
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.31 leaf
-
 Zea mays
-
4.1.1.31 leaf
-
 Arabidopsis thaliana
-
4.1.1.31 leaf
-
 Sorghum bicolor
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.31 phosphoenolpyruvate + CO2
-
 Zea mays phosphate + oxaloacetate
-
 ir
4.1.1.31 phosphoenolpyruvate + CO2
-
 Arabidopsis thaliana phosphate + oxaloacetate
-
 ir
4.1.1.31 phosphoenolpyruvate + CO2
-
 Sorghum bicolor phosphate + oxaloacetate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
4.1.1.31 C4 PEPC
-
 Zea mays
4.1.1.31 C4 PEPC
-
 Arabidopsis thaliana
4.1.1.31 C4 PEPC
-
 Sorghum bicolor
4.1.1.31 PEPC
-
 Zea mays
4.1.1.31 PEPC
-
 Arabidopsis thaliana
4.1.1.31 PEPC
-
 Sorghum bicolor
4.1.1.31 phosphoenolpyruvate carboxykinase
-
 Arabidopsis thaliana