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Literature summary extracted from

  • Gilbert, L.; Alhagdow, M.; Nunes-Nesi, A.; Quemener, B.; Guillon, F.; Bouchet, B.; Faurobert, M.; Gouble, B.; Page, D.; Garcia, V.; Petit, J.; Stevens, R.; Causse, M.; Fernie, A.R.; Lahaye, M.; Rothan, C.; Baldet, P.
    GDP-D-mannose 3,5-epimerase (GME) plays a key role at the intersection of ascorbate and non-cellulosic cell-wall biosynthesis in tomato (2009), Plant J., 60, 499-508.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.1.3.18 additional information construction of transgenic tomato lines RNAi-silenced for GME, RNAi silencing of GME in tomato effectively reduces ascorbate content in the plant, leading to ROS accumulation, leaf bleaching and developmental defects. Transgenic plants display strong alterations in cell-wall composition, with a considerable impact on plant and fruit mechanical properties, GME-silenced lines have increased fragility, phenotype, overview Solanum lycopersicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.18 GDP-D-mannose Solanum lycopersicum
-
 GDP-L-galactose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.18 Solanum lycopersicum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.1.3.18 leaf
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.18 GDP-D-mannose
-
 Solanum lycopersicum GDP-L-galactose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.1.3.18 GDP-D-mannose 3,5-epimerase
-
 Solanum lycopersicum
5.1.3.18 GME
-
 Solanum lycopersicum

General Information

EC Number General Information Comment Organism
5.1.3.18 metabolism GME is a central enzyme of the major ascorbate biosynthesis pathway in higher plants, it play a key role in the regulation of ascorbate biosynthesis in plants, adjusting the balance between ascorbate and cell-wall monosaccharide biosynthesis. GDP-D-mannose synthesis is the initial step in the pathway of ascorbate biosynthesis, and GDP-D-mannose is also a known precursor for the synthesis of D-mannose, L-fucose and L-galactose, and therefore for hemicelluloses such s the (galacto)glucomannans and for the pectin rhamnogalacturonan II Solanum lycopersicum