BRENDA - Enzyme Database show

Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis

Mateuszuk, L.; Khomich, T.I.; Slominska, E.; Gajda, M.; Wojcik, L.; Lomnicka, M.; Gwozdz, P.; Chlopicki, S.; Pharmacol. Rep. 61, 76-85 (2009)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.1
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus C57/BL6J
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.1
Mus musculus
-
C57BL/6J mice
-
2.1.1.1
Mus musculus C57/BL6J
-
C57BL/6J mice
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
adipose tissue
-
Mus musculus
-
2.1.1.1
adrenal gland
-
Mus musculus
-
2.1.1.1
brain
-
Mus musculus
-
2.1.1.1
carcinoma cell
-
Mus musculus
-
2.1.1.1
heart
-
Mus musculus
-
2.1.1.1
kidney
-
Mus musculus
-
2.1.1.1
liver
high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview
Mus musculus
-
2.1.1.1
lung
-
Mus musculus
-
2.1.1.1
placenta
-
Mus musculus
-
2.1.1.1
skeletal muscle
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + 4-methylnicotinamide
assay for fluorometric determination of enzyme activity
706094
Mus musculus
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + 4-methylnicotinamide
assay for fluorometric determination of enzyme activity
706094
Mus musculus C57/BL6J
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
706094
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
706094
Mus musculus C57/BL6J
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.1.1.1
37
-
assay at
Mus musculus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
8.6
-
assay at, substrate 4-methoxybenzaldehyde
Mus musculus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.1
S-adenosyl-L-methionine
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.1
S-adenosyl-L-methionine
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.1
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus C57/BL6J
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
adipose tissue
-
Mus musculus
-
2.1.1.1
adrenal gland
-
Mus musculus
-
2.1.1.1
brain
-
Mus musculus
-
2.1.1.1
carcinoma cell
-
Mus musculus
-
2.1.1.1
heart
-
Mus musculus
-
2.1.1.1
kidney
-
Mus musculus
-
2.1.1.1
liver
high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview
Mus musculus
-
2.1.1.1
lung
-
Mus musculus
-
2.1.1.1
placenta
-
Mus musculus
-
2.1.1.1
skeletal muscle
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + 4-methylnicotinamide
assay for fluorometric determination of enzyme activity
706094
Mus musculus
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + 4-methylnicotinamide
assay for fluorometric determination of enzyme activity
706094
Mus musculus C57/BL6J
S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
706094
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
706094
Mus musculus C57/BL6J
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.1.1.1
37
-
assay at
Mus musculus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
8.6
-
assay at, substrate 4-methoxybenzaldehyde
Mus musculus
Expression
EC Number
Organism
Commentary
Expression
2.1.1.1
Mus musculus
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
up
General Information
EC Number
General Information
Commentary
Organism
2.1.1.1
physiological function
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.1.1.1
physiological function
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
Mus musculus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.1.1.1
Mus musculus
progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels
up