Literature summary extracted from

Elsinghorst, P.W.; Haertig, W.; Goldhammer, S.; Grosche, J.; Guetschow, M.
A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques (2009), Org. Biomol. Chem., 7, 3940-3946.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.8	2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.8	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.8	butyrylthiocholine + H2O	-	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.8	butyrylcholinesterase	-	Homo sapiens
3.1.1.8	hBChE	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.1.1.8	25	-	assay at	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.1.1.8	7.3	-	assay at	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.1.1.8	0.000016	-	-	Homo sapiens	2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide

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Release 2023.1 (January 2023)