BRENDA - Enzyme Database show

Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?

Funamizu, N.; Okamoto, A.; Kamata, Y.; Misawa, T.; Uwagawa, T.; Gocho, T.; Yanaga, K.; Manome, Y.; Oncol. Rep. 23, 471-475 (2010)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
BxPC-3 cell
-
Homo sapiens
-
2.7.1.74
MiaPaCa-2 cell
-
Homo sapiens
-
2.7.1.74
PANC-1 cell
-
Homo sapiens
-
2.7.1.74
pancreatic cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
706027
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + gemcitabine
i.e. difluorodeoxycytidine
706027
Homo sapiens
ADP + gemcitabine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
BxPC-3 cell
-
Homo sapiens
-
2.7.1.74
MiaPaCa-2 cell
-
Homo sapiens
-
2.7.1.74
PANC-1 cell
-
Homo sapiens
-
2.7.1.74
pancreatic cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
706027
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + gemcitabine
i.e. difluorodeoxycytidine
706027
Homo sapiens
ADP + gemcitabine 5'-phosphate
-
-
-
?