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Literature summary extracted from

  • Santo, L.; Vallet, S.; Hideshima, T.; Cirstea, D.; Ikeda, H.; Pozzi, S.; Patel, K.; Okawa, Y.; Gorgun, G.; Perrone, G.; Calabrese, E.; Yule, M.; Squires, M.; Ladetto, M.; Boccadoro, M.; Richardson, P.G.; Munshi, N.C.; Anderson, K.C.; Raje, N.
    AT7519, a novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition (2010), Oncogene, 29, 2325-2336.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.26 AT7519 0.0005 mM AT7519 inhibits glycogen synthase kinase 3beta phosphorylation, AT7519 dephosphorylates GSK-3beta independent of inhibition of transcription Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.26 medicine GSK-3beta is a therapeutic target in cancer treatment Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.26 ATP + beta-catenin Homo sapiens
-
 ADP + phosphorylated beta-catenin
-
 ?
2.7.11.26 ATP + c-Myc Homo sapiens
-
 ADP + phosphorylated c-Myc
-
 ?
2.7.11.26 ATP + cyclin D Homo sapiens
-
 ADP + phosphorylated cyclin D
-
 ?
2.7.11.26 ATP + cyclin E Homo sapiens
-
 ADP + phosphorylated cyclin E
-
 ?
2.7.11.26 ATP + glycogen synthase Homo sapiens
-
 ADP + glycogen synthase phosphate
-
 ?
2.7.11.26 ATP + nuclear factor-kappaB Homo sapiens
-
 ADP + phosphorylated nuclear factor-kappaB
-
 ?
2.7.11.26 ATP + p53 Homo sapiens
-
 ADP + phosphorylated p53
-
 ?
2.7.11.26 ATP + protein tau Homo sapiens
-
 ADP + protein tau phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.26 phosphoprotein GSK-3beta is activated via phosphorylation at Ser9 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 MM1-S cell
-
 Homo sapiens
-
2.7.11.26 multiple myeloma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + beta-catenin
-
 Homo sapiens ADP + phosphorylated beta-catenin
-
 ?
2.7.11.26 ATP + c-Myc
-
 Homo sapiens ADP + phosphorylated c-Myc
-
 ?
2.7.11.26 ATP + cyclin D
-
 Homo sapiens ADP + phosphorylated cyclin D
-
 ?
2.7.11.26 ATP + cyclin E
-
 Homo sapiens ADP + phosphorylated cyclin E
-
 ?
2.7.11.26 ATP + glycogen synthase
-
 Homo sapiens ADP + glycogen synthase phosphate
-
 ?
2.7.11.26 ATP + nuclear factor-kappaB
-
 Homo sapiens ADP + phosphorylated nuclear factor-kappaB
-
 ?
2.7.11.26 ATP + p53
-
 Homo sapiens ADP + phosphorylated p53
-
 ?
2.7.11.26 ATP + protein tau
-
 Homo sapiens ADP + protein tau phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 glycogen synthase kinase-3beta
-
 Homo sapiens
2.7.11.26 GSK-3beta
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.26 ATP
-
 Homo sapiens