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Literature summary extracted from

  • Yamaoka, K.; Tanaka, Y.
    Jak inhibitor: possibility and mechanism as a new disease modifying anti-rheumatic drug (2009), Nihon Rinsho Meneki Gakkai Kaishi, 32, 85-91.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 CP690,550 targeting Jak3 Homo sapiens
2.7.10.2 INCB18424 targeting Jak1/2 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 dendritic cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Jak1
-
 Homo sapiens
2.7.10.2 JAK2
-
 Homo sapiens
2.7.10.2 Jak3
-
 Homo sapiens
2.7.10.2 Janus kinase
-
 Homo sapiens
2.7.10.2 Tyk2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
 Homo sapiens