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Literature summary extracted from

  • Sitz, J.H.; Baumgaertel, K.; Haemmerle, B.; Papadopoulos, C.; Hekerman, P.; Tejedor, F.J.; Becker, W.; Lutz, B.
    The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4 (2008), Neuroscience, 157, 596-605.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.1 EGFP-tagged DYRK1A is expressed in HEK-293 cell Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.12.1 harmine specific inhibitor of DYRK1A Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.1 ATP + neurodegeneration-related septin 4 Mus musculus SEPT4, also known as Pnutl2/CDCrel-2 ADP + phosphorylated neurodegeneration-related septin 4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.1 Mus musculus Q61214
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.1 brain
-
 Mus musculus
-
2.7.12.1 neocortex
-
 Mus musculus
-
2.7.12.1 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.1 ATP + neurodegeneration-related septin 4 SEPT4, also known as Pnutl2/CDCrel-2 Mus musculus ADP + phosphorylated neurodegeneration-related septin 4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.1 dual-specificity tyrosine phosphorylation-regulated kinase 1A
-
 Mus musculus
2.7.12.1 DYRK1A
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.12.1 ATP
-
 Mus musculus