Literature summary extracted from

Yasuda, S.; Yasuda, T.; Hui, Y.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells (2009), Neurosci. Res., 64, 273-279.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.6	tropolone	complete inhibition at 0.25 mM	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.1.1.6	cytosol	the majority of COMT dopamine-methylating activity is found to be present in the cytosol	Homo sapiens	5829	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.6	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.6	SK-N-MC cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.6	dopamine + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + 3-O-methyldopamine	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.6	COMT	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.1.1.6	metabolism	concerted action of cytosolic sulfotransferase SULT1A3 and COMT in dopamine metabolism	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)