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Literature summary extracted from

  • Suganthy, N.; Karutha Pandian, S.; Pandima Devi, K.
    Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata (2010), Neurosci. Lett., 468, 216-219.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 donepezil standard drug against Alzheimer's disease, mixed type inhibition, Ki: 1.41 mg/ml Oreochromis niloticus
3.1.1.8 methanolic exrtact of Dictyota dichotoma methanolic extract, noncompetitive type inhibition, , Ki: 0.9 mg/ml Oreochromis niloticus
3.1.1.8 methanolic exrtact of Enteromorpha intestinalis methanolic extract, mixed-type inhibition, Ki: 0.95 mg/ml Oreochromis niloticus
3.1.1.8 methanolic exrtact of Hypnea valentine methanolic extract, mixed-type inhibition, Ki: 0.75 mg/ml Oreochromis niloticus
3.1.1.8 methanolic exrtact of Ulva reticulate methanolic extract, mixed-type inhibition, Ki: 0.6 mg/ml Oreochromis niloticus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.8 2.38
-
 butyrylthiocholine iodide with methanolic extract of Hypnea valentine (1.3-6.5 mg/ml), Vmax: 190.9 nmole/min/mg protein Oreochromis niloticus
3.1.1.8 2.63
-
 butyrylthiocholine iodide with methanolic extract of Ulva reticulate (2-10 mg/ml), Vmax: 182.6 nmole/min/mg protein Oreochromis niloticus
3.1.1.8 2.77
-
 butyrylthiocholine iodide with methanolic extract of Dictyota dichotoma (1.3 - 6.5 mg/ml), Vmax: 232.8 nmole/min/mg protein Oreochromis niloticus
3.1.1.8 2.83
-
 butyrylthiocholine iodide with inhibitor donepezil (0.4-4.15 mg/ml), Vmax: 183.6 nmole/min/mg protein Oreochromis niloticus
3.1.1.8 2.87
-
 butyrylthiocholine iodide with methanolic extract of Enteromorpha intestinalis (1.4 - 7 mg/ml), Vmax: 192.8 nmole/min/mg protein Oreochromis niloticus
3.1.1.8 3.9
-
 butyrylthiocholine iodide Vmax: 245.6 nmole/min/mg protein Oreochromis niloticus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Oreochromis niloticus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylthiocholine iodide + H2O
-
 Oreochromis niloticus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BuChE
-
 Oreochromis niloticus
3.1.1.8 butyrylcholinesterase
-
 Oreochromis niloticus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.8 additional information
-
 assay at room temperature Oreochromis niloticus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.8 8
-
 assay at Oreochromis niloticus