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Literature summary extracted from

  • Helser, T.L.; Davies, J.E.; Dahlberg, J.E.
    Mechanism of kasugamycin resistance in Escherichia coli (1972), Nat. New Biol., 235, 6-9.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.182 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA Escherichia coli
-
 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.182 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.182 partial Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.182 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
-
 Escherichia coli 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?
2.1.1.182 4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA 4 methyl groups are incorporated per 16S RNA molecule, both adenine residues in the 16S RNA sequence AACCUG are dimethylated Escherichia coli 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

General Information

EC Number General Information Comment Organism
2.1.1.182 malfunction strains lacking the methylase are resistant to kasugamycin Escherichia coli