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Literature summary extracted from

  • Kong, X.; Fan, H.; Liu, X.; Wang, R.; Liang, J.; Gupta, N.; Chen, Y.; Fang, F.; Chang, Y.
    Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase (2009), Mol. Pharmacol., 76, 854-860.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.3 uridine + phosphate Homo sapiens
-
 uracil + alpha-D-ribose 1-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 breast cancer cell
-
 Homo sapiens
-
2.4.2.3 Colo-320 cell
-
 Homo sapiens
-
2.4.2.3 colonic cancer cell
-
 Homo sapiens
-
2.4.2.3 HCT-166 cell
-
 Homo sapiens
-
2.4.2.3 MCF-7 cell
-
 Homo sapiens
-
2.4.2.3 SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.4.2.3 UPase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.3 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.3 7.5
-
 assay at Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.2.3 Homo sapiens the peroxisome proliferator-activated receptor gamma coactivator-1alpha induces the enzyme in cancer cells via binding of a nuclear receptor, leading to enhanced antiproliferative activity of 5-deoxy-5-fluorouridine, overview. The activation is abolished by XCT790, i.e. 3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide. Molecular mechanisms, overview up

General Information

EC Number General Information Comment Organism
2.4.2.3 physiological function the enzyme contributes to the antineoplastic activity of 5'-deoxy-5-fluorouridine. The peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase, overview Homo sapiens