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Literature summary extracted from
- Anthocyanins as lipoxygenase inhibitors (2009), Mol. Nutr. Food Res., 53, 617-624.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | medicine | powerful inhibitory properties of anthocyanins (delphinidin glycosides) towards lipoxygenases in relation to their currently known availability in human metabolism may in vivo prevent inflammatory diseases | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.12 | cyanidin | from Aronia melanocarpa concentrate, inhibits in a concentration-dependent manner | Glycine max |  |
| 1.13.11.12 | cyanidin 3-O-arabinoside | from Aronia melanocarpa concentrate, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | cyanidin 3-O-galactoside | from Aronia melanocarpa concentrate, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | cyanidin 3-O-glucoside | from Aronia melanocarpa concentrate, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | delphinidin | from Vaccinium myrtillus berries, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | delphinidin 3-O-arabinoside | from Vaccinium myrtillus berries, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | delphinidin 3-O-galactoside | from Vaccinium myrtillus berries, most effective inhibitor, uncompetitive type, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | delphinidin 3-O-glucoside | from Vaccinium myrtillus berries, most effective inhibitor, uncompetitive type, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | additional information | is not inhibited by malvidin 3-O-glucoside from Vaccinium myrtillus berries | Glycine max | |
| 1.13.11.12 | peonidin | from Vaccinium macrocarpon juice, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | peonidin 3-O-arabinoside | from Vaccinium macrocarpon juice, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | peonidin 3-O-galactoside | from Vaccinium macrocarpon juice, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.12 | peonidin 3-O-glucoside | from Vaccinium macrocarpon juice, inhibits in a concentration-dependent manner | Glycine max | |
| 1.13.11.34 | delphinidin 3-O-galactoside | from Vaccinium myrtillus berries, strong inhibitor, in a concentration-dependent manner | Homo sapiens | |
| 1.13.11.34 | delphinidin 3-O-glucoside | from Vaccinium myrtillus berries, strong inhibitor, in a concentration-dependent manner | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.12 | Glycine max | - |
- |
- |
| 1.13.11.34 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | granulocyte | - |
Homo sapiens | - |
| 1.13.11.34 | neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.12 | linoleate + O2 | - |
Glycine max | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
| 1.13.11.34 | arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.12 | lipoxygenase-1 | - |
Glycine max |
| 1.13.11.34 | 5-lipoxygenase | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.12 | 0.00043 | - |
- |
Glycine max | delphinidin 3-O-glucoside | |
| 1.13.11.12 | 0.00046 | - |
- |
Glycine max | delphinidin 3-O-galactoside | |
| 1.13.11.12 | 0.18 | - |
- |
Glycine max | cyanidin 3-O-galactoside | |
| 1.13.11.12 | 0.25 | - |
- |
Glycine max | cyanidin 3-O-glucoside | |
| 1.13.11.12 | 0.27 | - |
- |
Glycine max | delphinidin | |
| 1.13.11.12 | 0.49 | - |
- |
Glycine max | delphinidin 3-O-arabinoside | |
| 1.13.11.12 | 0.58 | - |
- |
Glycine max | cyanidin | |
| 1.13.11.12 | 0.59 | - |
- |
Glycine max | peonidin | |
| 1.13.11.12 | 1.24 | - |
- |
Glycine max | cyanidin 3-O-arabinoside | |
| 1.13.11.12 | 31 | - |
- |
Glycine max | peonidin 3-O-arabinoside | |
| 1.13.11.12 | 37.5 | - |
- |
Glycine max | peonidin 3-O-glucoside | |
| 1.13.11.12 | 37.7 | - |
- |
Glycine max | peonidin 3-O-galactoside | |
| 1.13.11.34 | 0.00215 | - |
- |
Homo sapiens | delphinidin 3-O-glucoside | |
| 1.13.11.34 | 0.0069 | - |
- |
Homo sapiens | delphinidin 3-O-galactoside | |
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