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Literature summary extracted from

  • Chen, Y.L.; Montedonico, A.E.; Kauffman, S.; Dunlap, J.R.; Menn, F.M.; Reynolds, T.B.
    Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans (2010), Mol. Microbiol., 75, 1112-1132.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.8 Candida albicans
-
-
-
4.1.1.65 Candida albicans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.65 Phosphatidyl-L-serine
-
 Candida albicans Phosphatidylethanolamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.8 CHO1
-
 Candida albicans
2.7.8.8 phosphatidylserine synthetase
-
 Candida albicans
2.7.8.8 PS synthase
-
 Candida albicans
4.1.1.65 PS decarboxylase
-
 Candida albicans
4.1.1.65 PSD
-
 Candida albicans

General Information

EC Number General Information Comment Organism
2.7.8.8 malfunction a phosphatidylserine synthase deletion mutant lacks phosphatidylserine, has decreased phosphatidylethanolamine, exhibits defects in cell wall integrity, mitochondrial function, filamentous growth, and is avirulent in a mouse model of systemic candidiasis Candida albicans
2.7.8.8 physiological function the enzyme is essential for cell wall integrity and virulence in Candida albicans Candida albicans
4.1.1.65 malfunction psd1 and psd2 deletion mutants exhibit defects in filamentous growth Candida albicans
4.1.1.65 physiological function phosphatidylserine decarboxylase is essential for cell wall integrity and virulence in Candida albicans Candida albicans