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Literature summary extracted from

  • Zhu, Y.; Prives, C.
    p53 and Metabolism: The GAMT connection (2009), Mol. Cell, 36, 351-352.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.2 Mus musculus
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate
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 Mus musculus S-adenosyl-L-homocysteine + creatine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.2 GAMT
-
 Mus musculus
2.1.1.2 guanidinoacetate methyltransferase
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 Mus musculus

Expression

EC Number Organism Comment Expression
2.1.1.2 Mus musculus both RNA and protein levels of GAMT are increased in a p53-dependent manner after various inducers of genotoxic stress (etoposide, H2O2, and gamma-irradiation), glucose deprivation induces GAMT in a p53-dependent manner, GAMT mRNA and protein are increased in several tissues of glucose-deprived p53 wild-type mice while remaining unchanged in the same tissues of p53 null mice up

General Information

EC Number General Information Comment Organism
2.1.1.2 malfunction loss of GAMT causes a creatine deficiency syndrome that is characterized by neurological and motor dysfunction as well as developmental delay/regression, mental retardation, and related defects Mus musculus