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Literature summary extracted from

  • Miotto, B.; Struhl, K.
    HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by geminin (2010), Mol. Cell, 37, 57-66.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.48 additional information coexpression of HBO1 and Jade-1 increases histone acetylation and MCM complex loading, loading, whereas overexpression of HBO1 alone does not Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.48 expression of mutant HATG485. Coexpression of HBO1 and Jade-1 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.48 G485 a HBO1 mutant, which contains a mutation of an invariant glycine in the histone acetyltransferase domain that abolishes enzymatic activity Homo sapiens
2.3.1.48 additional information a histone acetylase-defective mutant of HBO1 bound at origins is unable to load the MCM complex, also overexpression of the Set8 histone H4 tail-binding domain specifically inhibits MCM loading Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 geminin a Cdt1 repressor, inhibits HBO1 acetylase activity in a a Cdt1-dependent manner in the context of a Cdt1-HBO1 complex, and it associates with origins and inhibits H4 acetylation and licensing in vivo, but geminin does not block the interaction of Cdt1 with HBO1 in vitro or Cdt1-dependent recruitment of HBO1 to replication origins in vivo Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 Homo sapiens HBO1 is an H4-specific histone acetylase, and is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is essential for DNA licensing of replication origins, where it controls H4 acetylation at the origins. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition CoA + acetylhistone H4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 cell culture H4 acetylation at origins by HBO1 is cell-cycle regulated, with maximal activity at the G1/S transition Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4
-
 Homo sapiens CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + histone H4 HBO1 is an H4-specific histone acetylase, and is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is essential for DNA licensing of replication origins, where it controls H4 acetylation at the origins. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 HAT
-
 Homo sapiens
2.3.1.48 HBO1
-
 Homo sapiens
2.3.1.48 histone acetylase
-
 Homo sapiens