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Literature summary extracted from

  • Treharne, K.J.; Best, O.G.; Mehta, A.
    The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP (2009), Mol. Cell. Biochem., 329, 107-114.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.6 cytosol
-
Mus musculus 5829
-
2.7.4.6 cytosol
-
Ovis aries 5829
-
2.7.4.6 membrane
-
Mus musculus 16020
-
2.7.4.6 membrane
-
Homo sapiens 16020
-
2.7.4.6 membrane
-
Ovis aries 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.6 Mg2+ required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection Mus musculus
2.7.4.6 Mg2+ required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection Homo sapiens
2.7.4.6 Mg2+ required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.6 additional information Mus musculus NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways ?
-
?
2.7.4.6 additional information Homo sapiens NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways ?
-
?
2.7.4.6 additional information Ovis aries NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.6 Homo sapiens
-
-
-
2.7.4.6 Mus musculus
-
-
-
2.7.4.6 Ovis aries
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.4.6 phosphoprotein GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP Mus musculus
2.7.4.6 phosphoprotein GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP Homo sapiens
2.7.4.6 phosphoprotein GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.6 airway epithelium
-
Mus musculus
-
2.7.4.6 airway epithelium
-
Homo sapiens
-
2.7.4.6 airway epithelium
-
Ovis aries
-
2.7.4.6 bronchial epithelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.6 ATP + NDP
-
Mus musculus ADP + NTP
-
?
2.7.4.6 ATP + NDP
-
Homo sapiens ADP + NTP
-
?
2.7.4.6 ATP + NDP
-
Ovis aries ADP + NTP
-
?
2.7.4.6 additional information NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways Mus musculus ?
-
?
2.7.4.6 additional information NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways Homo sapiens ?
-
?
2.7.4.6 additional information NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways Ovis aries ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.6 NDPK
-
Mus musculus
2.7.4.6 NDPK
-
Homo sapiens
2.7.4.6 NDPK
-
Ovis aries
2.7.4.6 NM23
-
Mus musculus
2.7.4.6 NM23
-
Homo sapiens
2.7.4.6 NM23
-
Ovis aries
2.7.4.6 nucleoside diphosphate kinase
-
Mus musculus
2.7.4.6 nucleoside diphosphate kinase
-
Homo sapiens
2.7.4.6 nucleoside diphosphate kinase
-
Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.6 ATP
-
Mus musculus
2.7.4.6 ATP
-
Homo sapiens
2.7.4.6 ATP
-
Ovis aries

Expression

EC Number Organism Comment Expression
2.7.4.6 Homo sapiens in human airway cells exposed to hypoxia (3% oxygen) membrane-bound and cytosolic NDPK is inhibited down