EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.4.6 | cytosol | - |
Mus musculus | 5829 | - |
2.7.4.6 | cytosol | - |
Ovis aries | 5829 | - |
2.7.4.6 | membrane | - |
Mus musculus | 16020 | - |
2.7.4.6 | membrane | - |
Homo sapiens | 16020 | - |
2.7.4.6 | membrane | - |
Ovis aries | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.6 | Mg2+ | required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection | Mus musculus | |
2.7.4.6 | Mg2+ | required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection | Homo sapiens | |
2.7.4.6 | Mg2+ | required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection | Ovis aries |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.6 | additional information | Mus musculus | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | ? | - |
? | |
2.7.4.6 | additional information | Homo sapiens | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | ? | - |
? | |
2.7.4.6 | additional information | Ovis aries | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.6 | Homo sapiens | - |
- |
- |
2.7.4.6 | Mus musculus | - |
- |
- |
2.7.4.6 | Ovis aries | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.4.6 | phosphoprotein | GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP | Mus musculus |
2.7.4.6 | phosphoprotein | GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP | Homo sapiens |
2.7.4.6 | phosphoprotein | GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP | Ovis aries |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.4.6 | airway epithelium | - |
Mus musculus | - |
2.7.4.6 | airway epithelium | - |
Homo sapiens | - |
2.7.4.6 | airway epithelium | - |
Ovis aries | - |
2.7.4.6 | bronchial epithelial cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.6 | ATP + NDP | - |
Mus musculus | ADP + NTP | - |
? | |
2.7.4.6 | ATP + NDP | - |
Homo sapiens | ADP + NTP | - |
? | |
2.7.4.6 | ATP + NDP | - |
Ovis aries | ADP + NTP | - |
? | |
2.7.4.6 | additional information | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | Mus musculus | ? | - |
? | |
2.7.4.6 | additional information | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | Homo sapiens | ? | - |
? | |
2.7.4.6 | additional information | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | Ovis aries | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.4.6 | NDPK | - |
Mus musculus |
2.7.4.6 | NDPK | - |
Homo sapiens |
2.7.4.6 | NDPK | - |
Ovis aries |
2.7.4.6 | NM23 | - |
Mus musculus |
2.7.4.6 | NM23 | - |
Homo sapiens |
2.7.4.6 | NM23 | - |
Ovis aries |
2.7.4.6 | nucleoside diphosphate kinase | - |
Mus musculus |
2.7.4.6 | nucleoside diphosphate kinase | - |
Homo sapiens |
2.7.4.6 | nucleoside diphosphate kinase | - |
Ovis aries |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.6 | ATP | - |
Mus musculus | |
2.7.4.6 | ATP | - |
Homo sapiens | |
2.7.4.6 | ATP | - |
Ovis aries |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.7.4.6 | Homo sapiens | in human airway cells exposed to hypoxia (3% oxygen) membrane-bound and cytosolic NDPK is inhibited | down |