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Literature summary extracted from

  • Gulshan, K.; Shahi, P.; Moye-Rowley, W.S.
    Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance (2010), Mol. Biol. Cell, 21, 443-455.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.65 Pdr17 the presence of a phosphatidylinositol transfer protein called Pdr17 is required for Psd2 function Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.65 endosome Psd2 Saccharomyces cerevisiae 5768
-
4.1.1.65 mitochondrion PSD1 Saccharomyces cerevisiae 5739
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.65 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.65 Phosphatidyl-L-serine
-
 Saccharomyces cerevisiae Phosphatidylethanolamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.65 PSD1
-
 Saccharomyces cerevisiae
4.1.1.65 PSD2
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
4.1.1.65 malfunction loss of Psd2 causes cells to acquire sensitivity to cadmium even though Psd1 remains intact, loss of Psd2 causes a specific reduction in vacuolar membrane phosphatidylethanolamine levels, whereas total phosphatidylethanolamine levels are not significantly affected Saccharomyces cerevisiae
4.1.1.65 physiological function the mitochondrial Psd1 provides roughly 70% of the phosphatidylethanolamine biosynthesis in the cell with Psd2 carrying out the remainder, Psd2 action enhances Ycf1-dependent transport activity Saccharomyces cerevisiae