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Literature summary extracted from

  • Helmann, J.D.
    RNA polymerase: a nexus of gene regulation (2009), Methods, 47, 1-5.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.6 additional information interaction of elongation factors with RNAP, such as NusG and RfaH, affects the frequency and duration of pausing during transcription Bacillus subtilis
2.7.7.6 additional information interaction of elongation factors with RNAP, such as NusG and RfaH, affects the frequency and duration of pausing during transcription Escherichia coli
2.7.7.6 Rho in response to the Rho termination factor, RNA synthesis ceases and the completed transcript is released Bacillus subtilis
2.7.7.6 Rho in response to the Rho termination factor, RNA synthesis ceases and the completed transcript is released Escherichia coli
2.7.7.6 sigma factor a dissociable specificity sigma factor, regulated by factors such as anti-sigma factors, which can sequester r factors and prevent core association, and possibly by factors that enhance sigma-core association Escherichia coli
2.7.7.6 sigma factor a dissociable specificity sigma factor, regulated by factors such as anti-sigma factors, which can sequester sigma factors and prevent core association, and possibly by factors that enhance sigma-core association Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn Bacillus subtilis RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter diphosphate + RNAn+1
-
?
2.7.7.6 nucleoside triphosphate + RNAn Escherichia coli RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter diphosphate + RNAn+1
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Bacillus subtilis
-
-
-
2.7.7.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn
-
Bacillus subtilis diphosphate + RNAn+1
-
?
2.7.7.6 nucleoside triphosphate + RNAn
-
Escherichia coli diphosphate + RNAn+1
-
?
2.7.7.6 nucleoside triphosphate + RNAn RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter Bacillus subtilis diphosphate + RNAn+1
-
?
2.7.7.6 nucleoside triphosphate + RNAn RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression, synthesis of RNA transcripts of many thousands of nucleotides without dissociation. Energy, in the form of nucleoside triphosphates, fuels the synthesis of an RNA polymer complementary to specific regions of the DNA template. Like all macromolecular synthesis, RNA synthesis can be divided into three general phases: initiation, elongation, and termination. Importantly, each of these phases can be a target of regulation. Promoter recognition, binding at the extended promoter recognition region, and transcript initiation, RNAP prefers to initiate transcription within a narrow window located between 6 and 9 bp downstream of the -10 element, promoter clearance and elongation, termination and recycling, mechanisms and regulation , overview. The process of start site selection can be governed by the availability of either the +1 or the +2 NTP, depending on the promoter Escherichia coli diphosphate + RNAn+1
-
?

Subunits

EC Number Subunits Comment Organism
2.7.7.6 multimer bacterial RNAP is a multisubunit enzyme and consists of a core polymerase containing the beta, beta' , and two alpha subunits, together with one or more omega subunits, and a dissociable specificity factor sigma Bacillus subtilis
2.7.7.6 multimer bacterial RNAP is a multisubunit enzyme and consists of a core polymerase containing the beta, beta' , and two alpha subunits, together with one or more omega subunits, and a dissociable specificity factor sigma Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 RNA polymerase
-
Bacillus subtilis
2.7.7.6 RNA polymerase
-
Escherichia coli
2.7.7.6 RNAP
-
Bacillus subtilis
2.7.7.6 RNAP
-
Escherichia coli

General Information

EC Number General Information Comment Organism
2.7.7.6 physiological function RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression Bacillus subtilis
2.7.7.6 physiological function RNAP is an exceptionally complex enzyme that can be thought of as the engine of gene expression Escherichia coli