EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.21.1.1 | FAD | - |
Bos taurus | |
1.21.1.1 | FMN | - |
Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.21.1.1 | 3,5-diiodo-L-tyrosine | pronounced substrate inhibition above 5 microM | Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.1.1 | Bos taurus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.21.1.1 | - |
Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.21.1.1 | thyroid gland | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.1.1 | 3,5-diiodo-L-tyrosine + dithionite | solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM | Bos taurus | 3-iodo-L-tyrosine + ? + I- | - |
? | |
1.21.1.1 | 3,5-diiodo-L-tyrosine + NADPH + H+ | solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM | Bos taurus | 3-iodo-L-tyrosine + NADP+ + I- | - |
? |