EC Number | Application | Comment | Organism |
---|---|---|---|
2.4.1.212 | medicine | HAS 2 appears to be a major contributor to the baseline levels of hyaluronan. Reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response. In hydrated animals, the diuretic response is followed by a 58% elevation in papillary hyaluronan and a 45% reduction in the excreted urinary hyaluronidase activity. No difference is determined in HAS 13 mRNA or HYAL 1, 34 mRNA expression. In dehydrated animals, antidiuresis is followed by a 22% reduction in papillary hyaluronan and a 62% elevation in excreted urinary hyaluronidase activity. Plasma vasopressin is 2.8-fold higher in dehydrated versus hydrated rats | Rattus norvegicus |
2.4.1.212 | medicine | in hydrated animals, the diuretic response is followed by a 58% elevation in papillary hyaluronan and a 45% reduction in the excreted urinary hyaluronidase activity. No difference is determined in HAS 13 mRNA or HYAL 1, 34 mRNA expression. In dehydrated animals, antidiuresis is followed by a 22% reduction in papillary hyaluronan and a 62% elevation in excreted urinary hyaluronidase activity. Plasma vasopressin is 2.8-fold higher in dehydrated versus hydrated rats | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.212 | Rattus norvegicus | - |
- |
- |
2.4.1.212 | Rattus norvegicus | O35776 | isoform HAS2 | - |
3.2.1.35 | Rattus norvegicus | - |
- |
- |
3.2.1.35 | Rattus norvegicus | Q76HM9 | - |
- |
3.2.1.35 | Rattus norvegicus | Q76HN1 | - |
- |
3.2.1.35 | Rattus norvegicus | Q9Z2Q3 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.212 | kidney | strong expression of HAS2 mRNA | Rattus norvegicus | - |
2.4.1.212 | kidney | weak expression of HAS1 and HAS3 mRNA | Rattus norvegicus | - |
3.2.1.35 | kidney | isoform HYAL 4 has little expression in the renal papilla | Rattus norvegicus | - |
3.2.1.35 | kidney | isoforms HYAL 1 is highly expressed in the renal papilla | Rattus norvegicus | - |
3.2.1.35 | kidney | isoforms HYAL 2 is highly expressed in the renal papilla | Rattus norvegicus | - |
3.2.1.35 | kidney | isoforms HYAL 3 is highly expressed in the renal papilla | Rattus norvegicus | - |
3.2.1.35 | urine | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.1.35 | hyaluronan + 2 H2O | - |
Rattus norvegicus | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.35 | Hyal 1 | isoform | Rattus norvegicus |
3.2.1.35 | HYAL 2 | isoform | Rattus norvegicus |
3.2.1.35 | HYAL 3 | isoform | Rattus norvegicus |
3.2.1.35 | HYAL 4 | isoform | Rattus norvegicus |
3.2.1.35 | hyaluronidase | - |
Rattus norvegicus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.4.1.212 | Rattus norvegicus | reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response | down |
3.2.1.35 | Rattus norvegicus | hyaluronidase activity is elevated in dehydrated rats | up |