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Literature summary extracted from

  • Ruegheimer, L.; Olerud, J.; Johnsson, C.; Takahashi, T.; Shimizu, K.; Hansell, P.
    Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status (2009), Matrix Biol., 28, 390-395.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.212 medicine HAS 2 appears to be a major contributor to the baseline levels of hyaluronan. Reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response. In hydrated animals, the diuretic response is followed by a 58% elevation in papillary hyaluronan and a 45% reduction in the excreted urinary hyaluronidase activity. No difference is determined in HAS 1–3 mRNA or HYAL 1, 3–4 mRNA expression. In dehydrated animals, antidiuresis is followed by a 22% reduction in papillary hyaluronan and a 62% elevation in excreted urinary hyaluronidase activity. Plasma vasopressin is 2.8-fold higher in dehydrated versus hydrated rats Rattus norvegicus
2.4.1.212 medicine in hydrated animals, the diuretic response is followed by a 58% elevation in papillary hyaluronan and a 45% reduction in the excreted urinary hyaluronidase activity. No difference is determined in HAS 1–3 mRNA or HYAL 1, 3–4 mRNA expression. In dehydrated animals, antidiuresis is followed by a 22% reduction in papillary hyaluronan and a 62% elevation in excreted urinary hyaluronidase activity. Plasma vasopressin is 2.8-fold higher in dehydrated versus hydrated rats Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Rattus norvegicus
-
-
-
2.4.1.212 Rattus norvegicus O35776 isoform HAS2
-
3.2.1.35 Rattus norvegicus
-
-
-
3.2.1.35 Rattus norvegicus Q76HM9
-
-
3.2.1.35 Rattus norvegicus Q76HN1
-
-
3.2.1.35 Rattus norvegicus Q9Z2Q3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 kidney strong expression of HAS2 mRNA Rattus norvegicus
-
2.4.1.212 kidney weak expression of HAS1 and HAS3 mRNA Rattus norvegicus
-
3.2.1.35 kidney isoform HYAL 4 has little expression in the renal papilla Rattus norvegicus
-
3.2.1.35 kidney isoforms HYAL 1 is highly expressed in the renal papilla Rattus norvegicus
-
3.2.1.35 kidney isoforms HYAL 2 is highly expressed in the renal papilla Rattus norvegicus
-
3.2.1.35 kidney isoforms HYAL 3 is highly expressed in the renal papilla Rattus norvegicus
-
3.2.1.35 urine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronan + 2 H2O
-
Rattus norvegicus N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 Hyal 1 isoform Rattus norvegicus
3.2.1.35 HYAL 2 isoform Rattus norvegicus
3.2.1.35 HYAL 3 isoform Rattus norvegicus
3.2.1.35 HYAL 4 isoform Rattus norvegicus
3.2.1.35 hyaluronidase
-
Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.4.1.212 Rattus norvegicus reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response down
3.2.1.35 Rattus norvegicus hyaluronidase activity is elevated in dehydrated rats up