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Literature summary extracted from

  • Keith, R.L.; Karoor, V.; Mozer, A.B.; Hudish, T.M.; Le, M.; Miller, Y.E.
    Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression (2010), Lung Cancer, 70, 37-42.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.3.99.4 medicine it is hypothesized that the combination of prostacyclin synthase overexpression and epidermal growth factor receptor tyrosine kinase inhibitor, EGFR TKI, would lead to augmented chemoprevention for lung cancer Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Mus musculus
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Mus musculus
-
 transgenic mice are developed using a construct consisting of the human SP-C promotor and full-length rat prostacyclin synthase cDNA
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 lung
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Mus musculus Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGIS
-
 Mus musculus
5.3.99.4 prostacyclin synthase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
5.3.99.4 Mus musculus for overexpression of prostacyclin synthase transgenic mice, carrying the rat prostacyclin synthase gene, are developed up