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Literature summary extracted from

  • Weyand, S.; Kefala, G.; Svergun, D.I.; Weiss, M.S.
    The three-dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation (2009), J. Struct. Funct. Genomics, 10, 209-217.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.20 expressed in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.20 hanging drop vapor diffusion method, using 20-23% (w/v) PEG-MME 5000, 0.1 M MES pH 6.1-6.6, and 60 mM (NH4)2SO4 Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.20 189000
-
 X-ray scattering Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.20 Mycobacterium tuberculosis P9WIU7
-
-
4.1.1.20 Mycobacterium tuberculosis H37Rv P9WIU7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.20
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.20 meso-2,6-Diaminoheptanedioate
-
 Mycobacterium tuberculosis L-Lysine + CO2
-
 ?
4.1.1.20 meso-2,6-Diaminoheptanedioate
-
 Mycobacterium tuberculosis H37Rv L-Lysine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.20 homodimer DAPDC is predominantly dimeric in solution Mycobacterium tuberculosis
4.1.1.20 homotetramer an equilibrium may exist between the dimeric and the tetrameric form, X-ray crystallography Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
4.1.1.20 DAPDC
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.20 pyridoxal 5'-phosphate
-
 Mycobacterium tuberculosis