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Literature summary extracted from
- Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR (2010), J. Struct. Biol., 169, 209-218.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.99.2 | for expression in Escherichia coli BL21DE3 cells | Mus musculus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.3.99.2 | DELTA1-24_C65A L-PGDS | mutant, preserves a disulfide bond between Cys89 and Cys186 | Mus musculus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.2 | 20000 | - |
L-PGDS | Mus musculus |
| 5.3.99.2 | 21000 | - |
L-PGDS bound to biliverdin | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.2 | Prostaglandin H2 | Mus musculus | - |
Prostaglandin D2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.2 | Mus musculus | O09114 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.3.99.2 | the DELTA1-24_C65A L-PGDS mutant is purified on a glutathione-Sepharose 4B column and incubated with thrombin to release the L-PGDS, the protein is further purified by gel filtration | Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.2 | Prostaglandin H2 | - |
Mus musculus | Prostaglandin D2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.99.2 | L-PGDS | - |
Mus musculus |
| 5.3.99.2 | lipocalin-type PGD synthase | - |
Mus musculus |
| 5.3.99.2 | lipocalin-type prostaglandin d synthase | - |
Mus musculus |
| 5.3.99.2 | Prostaglandin-H2 D-isomerase | - |
Mus musculus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.3.99.2 | physiological function | lipocalin-type prostaglandin D synthase acts as both a PGD2 synthase and an extracellular transporter for small lipophilic molecules | Mus musculus |
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Release 2023.1 (January 2023)
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