Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Miura, T.; Nishihara, M.; Miki, T.
    Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in myocardial protection against ischemia/reperfusion injury (2009), J. Pharmacol. Sci., 109, 162-167.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.26 medicine a significant inverse correlation is observed between level of phospho-GSK-3beta at the time of reperfusion and the extent of myocardium infarction in heart, phospho-GSK-3beta is a determinant of myocardial tolerance against reperfusion-induced necrosis. Thus, GSK-3beta is a target of therapy for cardioprotection upon reperfusion. Inactivation of GSK-3beta by phosphorylation at Ser9 elevates the threshold for mitochondrial permeability transition pore opening, which reduces myocyte necrosis. Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.26 phosphoprotein
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + p53
-
Homo sapiens ADP + p53 phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 glycogen synthase kinase-3beta
-
Homo sapiens
2.7.11.26 GSK-3beta
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.26 ATP
-
Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.26 malfunction inactivation of glycogen synthase kinase-3beta suppresses mitochondrial permeability transition pore opening and protects cardiomyocytes Homo sapiens