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Literature summary extracted from

  • Naoghare, P.K.; Kwon, H.T.; Song, J.M.
    On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase (2010), J. Pharm. Biomed. Anal., 51, 1-6.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 Aminoglutethimide
-
 Homo sapiens
1.17.3.2 cyclosporin A
-
 Homo sapiens
1.17.3.2 dithranol
-
 Homo sapiens
1.17.3.2 additional information development of a photodiode array chip-based xanthine assay for high-throughput screening of xanthiine oxidase inhibitors using a PDA microchip system, mechanism of drug action, enzyme-inhibitor interaction analysis, overview Homo sapiens
1.17.3.2 naringenin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + O2 + H2O Homo sapiens
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + O2 + H2O
-
 Homo sapiens urate + H2O2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
1.17.3.2 physiological function xanthine oxidase is a key enzyme that can catalyze the conversion of xanthine to uric acid, causing various diseases in humans Homo sapiens