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Literature summary extracted from

  • Kim, K.; Yang, J.; Kim, E.
    Diacylglycerol kinases in the regulation of dendritic spines (2010), J. Neurochem., 112, 577-587.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 dendrite
-
 Rattus norvegicus 30425
-
2.7.1.107 dendrite
-
 Mus musculus 30425
-
2.7.1.107 nucleus a portion of intracellular DGKzeta protein is localized to the nucleus Rattus norvegicus 5634
-
2.7.1.107 nucleus a portion of intracellular DGKzeta protein is localized to the nucleus Mus musculus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Mus musculus Q80UP3
-
-
2.7.1.107 Rattus norvegicus O08560
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 cerebellum
-
 Rattus norvegicus
-
2.7.1.107 cerebellum
-
 Mus musculus
-
2.7.1.107 hippocampus
-
 Rattus norvegicus
-
2.7.1.107 hippocampus
-
 Mus musculus
-
2.7.1.107 neuron dendritic spines on neuronal dendrites Rattus norvegicus
-
2.7.1.107 neuron dendritic spines on neuronal dendrites Mus musculus
-
2.7.1.107 olfactory bulb
-
 Rattus norvegicus
-
2.7.1.107 olfactory bulb
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Rattus norvegicus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKzeta
-
 Rattus norvegicus
2.7.1.107 DGKzeta
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
 Rattus norvegicus
2.7.1.107 ATP
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.107 Mus musculus DGKzeta mRNA levels are increased in mice on a high-fat diet, but are lower in those that become obese by a high-fat diet up
2.7.1.107 Rattus norvegicus DGKzeta mRNA levels are increased in rats on a high-fat diet, but are lower in those that become obese by a high-fat diet up

General Information

EC Number General Information Comment Organism
2.7.1.107 malfunction knockdown of DGKfzeta in cultured neurons decreases spine density Rattus norvegicus
2.7.1.107 malfunction knockdown of DGKfzeta in cultured neurons decreases spine density Mus musculus
2.7.1.107 physiological function isoform DGKf appears to form a multi-protein complex with functionally related proteins to organize efficient 1,2-diacylglycerol and 1,2-diacyl-sn-glycerol 3-phosphate signaling pathways at excitatory synapses, the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance, DGKzeta promotes neurite outgrowth Rattus norvegicus
2.7.1.107 physiological function isoform DGKf appears to form a multi-protein complex with functionally related proteins to organize efficient 1,2-diacylglycerol and 1,2-diacyl-sn-glycerol 3-phosphate signaling pathways at excitatory synapses, the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance, DGKzeta promotes neurite outgrowth Mus musculus