EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.3.2 | allopurinol | a time-dependent inhibitor | Bos taurus | |
1.17.3.2 | luteolin | competitive inhibition | Bos taurus | |
1.17.3.2 | additional information | no inhibition by curcumin in vitro | Bos taurus | |
1.17.3.2 | quercetin | competitive inhibition | Bos taurus | |
1.17.3.2 | silibinin | a mixed-type, not-time-dependent inhibitor | Bos taurus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.3.2 | additional information | - |
additional information | in vitro steady-state kinetic studies, kinetics with cofactor cytochrome C, overview | Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.3.2 | extracellular | secreted to milk | Bos taurus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.17.3.2 | Molybdenum | a molybdenum-containing enzyme | Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | 290000 | - |
- |
Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | xanthine + O2 + H2O | Bos taurus | xanthine oxidoreductase exists in two forms. The protein normally exists as xanthine dehydrogenase, XDH, EC 1.17.1.4, and utilizes NAD+ as its final electron acceptor in catalysis. Under certain conditions, most notably schemia and/or hypoxia, XDH can be converted to an oxidase form, XO, which can no longer reduce NAD+ and instead utilizes O2 exclusively as the terminal electron acceptor in the course of turnover. This conversion may occur either by oxidation of sulfhydryl groups and/or by limited proteolysis | urate + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.3.2 | Bos taurus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.17.3.2 | xanthine + H2O + O2 = urate + H2O2 | catalytic mechanism of xanthine oxidoreductase, overview | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.3.2 | milk | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.3.2 | xanthine + cytochrome c + H2O | - |
Bos taurus | urate + reduced cytochrome c | - |
? | |
1.17.3.2 | xanthine + O2 + H2O | xanthine oxidoreductase exists in two forms. The protein normally exists as xanthine dehydrogenase, XDH, EC 1.17.1.4, and utilizes NAD+ as its final electron acceptor in catalysis. Under certain conditions, most notably schemia and/or hypoxia, XDH can be converted to an oxidase form, XO, which can no longer reduce NAD+ and instead utilizes O2 exclusively as the terminal electron acceptor in the course of turnover. This conversion may occur either by oxidation of sulfhydryl groups and/or by limited proteolysis | Bos taurus | urate + H2O2 | - |
? | |
1.17.3.2 | xanthine + O2 + H2O | conversion of xanthine to uric acid at the molybdenum-containing active site | Bos taurus | urate + H2O2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.3.2 | XOR | - |
Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | 25 | - |
assay at | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.17.3.2 | 7.4 | - |
assay at | Bos taurus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.3.2 | 0.0012 | - |
quercetin | pH 7.4, 25°C | Bos taurus | |
1.17.3.2 | 0.0019 | - |
luteolin | pH 7.4, 25°C | Bos taurus |