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Literature summary extracted from

  • Sekhar Pagadala, N.; Arha, M.; Reddy, P.S.; Kumar, R.; Sirisha, V.L.; Prashant, S.; Janardhan Reddy, K.; Khan, B.; Rawal, S.K.; Kavi Kishor, P.B.
    Phylogenetic analysis, homology modelling, molecular dynamics and docking studies of caffeoyl-CoA-O-methyl transferase (CCoAOMT 1 and 2) isoforms isolated from subabul (Leucaena leucocephala) (2009), J. Mol. Model., 15, 203-221.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.104 isozyme CCoAOMT 1, DNA and amino acid sequence determination and analysis, phylogenetic analysis Leucaena leucocephala
2.1.1.104 isozyme CCoAOMT 2, DNA and amino acid sequence determination and analysis, phylogenetic analysis Leucaena leucocephala

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.104 S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA Leucaena leucocephala
-
 S-adenosyl-L-homocysteine + sinapoyl-CoA
-
 ?
2.1.1.104 S-adenosyl-L-methionine + caffeoyl-CoA Leucaena leucocephala
-
 S-adenosyl-L-homocysteine + feruloyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.104 Leucaena leucocephala Q0N3X0 CCoAOMT 2; i.e. Leucaena glauca, isozyme CCoAOMT 2
-
2.1.1.104 Leucaena leucocephala Q0N3X1 CCoAOMT 1; i.e. Leucaena glauca, isozyme CCoAOMT 1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.104 additional information CoA and caffeoyl CoA are binding with high affinity to the enzymes in the presence and absence of S-adenosyl-L-methionine, thereby with higher affinity to isozyme CCoAOMT2 than CCoAOMT1, molecular dynamics, simulations, and docking analysis, overview. Conserved active site residues Met58, Thr60, Val63, Glu82, Gly84, Ser90, Asp160, Asp162, Thr169, Asn191 and Arg203 in CCoAOMT1 and CCoAOMT2 enzymes create the positive charge to balance the negatively charged caffeoyl CoA and play an important role in maintaining a functional conformation and are directly involved in donor substrate binding Leucaena leucocephala ?
-
 ?
2.1.1.104 S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA
-
 Leucaena leucocephala S-adenosyl-L-homocysteine + sinapoyl-CoA
-
 ?
2.1.1.104 S-adenosyl-L-methionine + caffeoyl-CoA
-
 Leucaena leucocephala S-adenosyl-L-homocysteine + feruloyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.104 More isozyme CCoAOMT 1, three dimensional structure building by computational methods, overview Leucaena leucocephala
2.1.1.104 More isozyme CCoAOMT 2, three dimensional structure building by computational methods, overview Leucaena leucocephala

Synonyms

EC Number Synonyms Comment Organism
2.1.1.104 caffeoyl-CoA-O-methyl transferase 1
-
 Leucaena leucocephala
2.1.1.104 caffeoyl-CoA-O-methyl transferase 2
-
 Leucaena leucocephala
2.1.1.104 CCoAOMT 1
-
 Leucaena leucocephala
2.1.1.104 CCoAOMT 2
-
 Leucaena leucocephala

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.104 S-adenosyl-L-methionine
-
 Leucaena leucocephala

General Information

EC Number General Information Comment Organism
2.1.1.104 metabolism the enzyme is involved in lignin biosynthesis especially in the formation of cell wall ferulic esters of plants. It plays a pivotal role in the methylation of the 3-hydroxyl group of caffeoyl CoA Leucaena leucocephala