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Literature summary extracted from

  • Hein, T.W.; Qamirani, E.; Ren, Y.; Kuo, L.
    C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite (2009), J. Mol. Cell. Cardiol., 47, 196-202.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.3.99.4 medicine by impairing prostacyclin synthase function, and thus PGI2 release, C-reactive protein, CRP, could promote endothelial dysfunction and participate in the development of coronary artery disease Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 additional information proinflammatory C-reactive protein, CRP, selectively inhibits endothelium-dependent PGI2-induced dilation of coronary arterioles through peroxynitrite-mediated tyrosine nitration of prostacyclin synthase Sus scrofa
5.3.99.4 trans-2-phenyl cyclopropylamine
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.4 52000
-
 determined by SDS-PAGE and Western Blot analysis Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Sus scrofa
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 arteriole coronary arteriole Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Sus scrofa Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGI2 synthase
-
 Sus scrofa
5.3.99.4 PGI2-S
-
 Sus scrofa
5.3.99.4 prostacyclin synthase
-
 Sus scrofa