Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Karg, E.M.; Luderer, S.; Pergola, C.; Buehring, U.; Rossi, A.; Northoff, H.; Sautebin, L.; Troschuetz, R.; Werz, O.
    Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase (2009), J. Med. Chem., 52, 3474-3483.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.11.34 drug development due to their high potency against 5-lipoxygenase and the marked efficacy in biological systems, benzo[g]indole-3-carboxylates may have potential as anti-inflammatory therapeutics Homo sapiens
1.13.11.34 drug development due to their high potency against 5-lipoxygenase and the marked efficacy in biological systems, benzo[g]indole-3-carboxylates may have potential as anti-inflammatory therapeutics Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.34 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate prevents leukotriene B4 production in pleural exudates of carrageenan-treated rats, associated with reduced severity of pleurisy. Significantly reduces the inflammatory reaction measured as exudate volume (77%), inflammatory cell numbers (40%), and leukotriene B4 levels (49%) in the pleural exudates Rattus norvegicus
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-(allylamino)-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-(benzylamino)-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-(diallylamino)-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate
-
 Homo sapiens
1.13.11.34 N-(3-phenoxycinnamyl)-acetohydroxamic acid
-
 Homo sapiens
1.13.11.34 zileuton
-
 Homo sapiens
1.13.11.34 zileuton reduces exudate formation (77%), cell infiltration (41%), and leukotriene B4 exudate levels (66%) Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Ca2+ stimulation with calcium ionophore Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-
1.13.11.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 blood
-
 Homo sapiens
-
1.13.11.34 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Homo sapiens
1.13.11.34 5-lipoxygenase
-
 Rattus norvegicus
1.13.11.34 5-LO
-
 Homo sapiens
1.13.11.34 5-LO
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.000031
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000038
-
 recombinant 5-lipoxygenase Homo sapiens N-(3-phenoxycinnamyl)-acetohydroxamic acid
1.13.11.34 0.000045
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000049
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000067
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000084
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000086
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000095
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000096
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.000097
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00013
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00013
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00013
-
 recombinant 5-lipoxygenase Homo sapiens benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00014
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00015
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00015
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00016
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens N-(3-phenoxycinnamyl)-acetohydroxamic acid
1.13.11.34 0.00017
-
 recombinant 5-lipoxygenase Homo sapiens benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00023
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00025
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0003
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.00032
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00033
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.00034
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00035
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00044
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00045
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00048
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00049
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0005
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00052
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00052
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00058
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate
1.13.11.34 0.0006
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00065
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.00065
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0007
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0007
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0008
-
 recombinant 5-lipoxygenase Homo sapiens zileuton
1.13.11.34 0.0009
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens zileuton
1.13.11.34 0.0012
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0012
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0012
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0012
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate
1.13.11.34 0.0016
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0017
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0017
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0017
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0017
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0018
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.002
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.002
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0021
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0024
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0028
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0028
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0028
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0033
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0034
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-(benzylamino)-1H-indole-3-carboxylate
1.13.11.34 0.0034
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0035
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0035
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate
1.13.11.34 0.0039
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.004
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-(benzylamino)-1H-indole-3-carboxylate
1.13.11.34 0.0043
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate
1.13.11.34 0.0048
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
1.13.11.34 0.0055
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate
1.13.11.34 0.0055
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate
1.13.11.34 0.0057
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate
1.13.11.34 0.0065
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0069
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-(diallylamino)-1H-indole-3-carboxylate
1.13.11.34 0.007
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.0072
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0073
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate
1.13.11.34 0.0079
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0081
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0083
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0098
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0098
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.01
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.01
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.01
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate
1.13.11.34 0.0102
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.0125
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-(diallylamino)-1H-indole-3-carboxylate
1.13.11.34 0.0134
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate
1.13.11.34 0.03
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens methyl 2-(allylamino)-1H-indole-3-carboxylate
1.13.11.34 0.03
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate
1.13.11.34 0.03
-
 5-lipoxygenase inhibited in neutrophils Homo sapiens ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate
1.13.11.34 0.03
-
 recombinant 5-lipoxygenase Homo sapiens methyl 2-(allylamino)-1H-indole-3-carboxylate
1.13.11.34 0.03
-
 recombinant 5-lipoxygenase Homo sapiens ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate