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Literature summary extracted from

  • Ojogun, N.; Kuang, T.Y.; Shao, B.; Greaves, D.R.; Munford, R.S.; Varley, A.W.
    Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo (2009), J. Infect. Dis., 200, 1685-1693.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.77 medicine constitutive overexpression of AOAH in vivo hasten recovery from lipopolysaccharide exposure without interfering with the normal acute inflammatory response Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.77 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O detoxification of lipopolysaccharide Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.77 AOAH
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 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.77 7.2
-
 assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.77 malfunction transgenic mice overexpressing AOAH in dendritic cells and macrophages deacylate lipopolysaccharide more rapidly than wildtype controls. Transgenic mice are also protected from lipopolysaccharide-induced hepatosplenomegaly, recover more quickly from lipopolysaccharide-induced weight loss, and are more likely to survive when challenged with live Escherichia coli Mus musculus