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Literature summary extracted from

  • Hayakawa, Y.; Maeda, S.; Nakagawa, H.; Hikiba, Y.; Shibata, W.; Sakamoto, K.; Yanai, A.; Hirata, Y.; Ogura, K.; Muto, S.; Itai, A.; Omata, M.
    Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis (2009), J. Gastroenterol., 44, 935-943.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.10 medicine IKKbeta-targeted NF-kappaB blockade is an attractive therapeutic approach for the prevention of colitis-associated tumors Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 IMD-0354
-
 Mus musculus
2.7.11.10 NBD peptide NEMO-binding domain peptide Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 colon
-
 Mus musculus
-
2.7.11.10 J-774.1 cell
-
 Mus musculus
-
2.7.11.10 macrophage
-
 Mus musculus
-
2.7.11.10 MC-38 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.10 heterotrimer IkappaB kinase, IKK, consists of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit IKKgamma, NEMO Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase beta
-
 Mus musculus
2.7.11.10 IKKbeta
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Mus musculus