Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Miszczak-Zaborska, E.; Kubiak, R.; Bienkiewicz, A.; Bartkowiak, J.
    The cytosol activity of thymidine phosphorylase in endometrial cancer (2008), J. Exp. Clin. Cancer Res., 27, 64.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.4 cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 additional information Homo sapiens thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium ?
-
?
2.4.2.4 thymidine + phosphate Homo sapiens
-
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 blood platelet
-
Homo sapiens
-
2.4.2.4 endometrial carcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 additional information thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium Homo sapiens ?
-
?
2.4.2.4 thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
r

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 PD-ECGF
-
Homo sapiens
2.4.2.4 PD-ECGF/TP
-
Homo sapiens
2.4.2.4 platelet-derived endothelial cell growth factor
-
Homo sapiens
2.4.2.4 platelet-derived endothelial cell growth factor/thymidine phosphorylase
-
Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.4 malfunction thymidine phosphorylase promotes angiogenesis. The mechanism of endometrial angiogenesis involves the enzyme and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium Homo sapiens