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Literature summary extracted from

  • Blumenthal, E.M.
    Isoform- and cell-specific function of tyrosine decarboxylase in the Drosophila Malpighian tubule (2009), J. Exp. Biol., 212, 3802-3809.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.25 additional information the mutant allele of Tdc1, Tdc1f03311, reduces expression of the mature Tdc1 transcript by greater than 100fold Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.25 L-Tyrosine Drosophila melanogaster
-
 Tyramine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.25 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.25 malpighian tubule the non-neuronal isoform of TDC, Tdc1, is expressed in the principal cells of the Malpighian tubule Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.25 L-Tyrosine
-
 Drosophila melanogaster Tyramine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.25 TDC
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
4.1.1.25 malfunction Malpighian tubules isolated from Tdc1f03311 homozygous flies show no significant depolarization of their transepithelial potential or diuresis in response to tyrosine while retaining normal sensitivity to tyramine, the null mutant allele of the neuronal TDC isoform Tdc2 has no effect on either tyrosine or tyramine sensitivity Drosophila melanogaster
4.1.1.25 physiological function synthesis of tyramine by Tdc1 in the principal cells of the Malpighian tubule is required for physiological responses to tyrosine Drosophila melanogaster