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Literature summary extracted from

  • van Diermen, D.; Marston, A.; Bravo, J.; Reist, M.; Carrupt, P.A.; Hostettmann, K.
    Monoamine oxidase inhibition by Rhodiola rosea L. roots (2009), J. Ethnopharmacol., 122, 397-401.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.4.3.4 medicine Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 cinnamyl alcohol compound from Rhodiola rosea extract, inhibits both MAO A and MAO B Homo sapiens
1.4.3.4 Clorgyline inhibition of MAO A and MAO B Homo sapiens
1.4.3.4 epigallocatechin gallate dimer compound from Rhodiola rosea extract, inhibits both MAO A and MAO B Homo sapiens
1.4.3.4 L-deprenyl inhibition of MAO A and MAO B Homo sapiens
1.4.3.4 additional information Rhodiola rosea roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B, no inhibition of both isozymes by rosavin, rosarin, and rosin Homo sapiens
1.4.3.4 rhodiocyanoside A compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
1.4.3.4 rhodioloside B compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
1.4.3.4 rosiridin compound from Rhodiola rosea extract, inhibits both MAO A and MAO B Homo sapiens
1.4.3.4 salidroside compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
1.4.3.4 triandrin compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens
1.4.3.4 tyrosol compound from Rhodiola rosea extract, inhibits MAO B, not MAO A Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P27338
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-B
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 7.4
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 additional information
-
 pIC50 value of rosiridin for MAO B inhibition is 5.38, the pIC50 value for L-deprenyl is 7.23 for MAO B inhibition Homo sapiens additional information