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Literature summary extracted from

  • Sheng, C.; Ji, H.; Miao, Z.; Che, X.; Yao, J.; Wang, W.; Dong, G.; Guo, W.; Lue, J.; Zhang, W.
    Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design (2009), J. Comput. Aided Mol. Des., 23, 375-389.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.97 2-([[(1R,3S)-3-[[(5-chloro-7-methylnaphthalen-2-yl)methyl]amino]cyclohexyl]acetyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Leishmania major
2.3.1.97 2-([[(1R,3S)-3-[[(5-chloro-7-methylnaphthalen-2-yl)methyl]amino]cyclohexyl]acetyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Plasmodium falciparum
2.3.1.97 2-([[(1R,3S)-3-[[(5-chloro-7-methylnaphthalen-2-yl)methyl]amino]cyclohexyl]acetyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Trypanosoma brucei
2.3.1.97 2-([[4-(aminomethyl)cyclohexyl]carbonyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Leishmania major
2.3.1.97 2-([[4-(aminomethyl)cyclohexyl]carbonyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Plasmodium falciparum
2.3.1.97 2-([[4-(aminomethyl)cyclohexyl]carbonyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Trypanosoma brucei
2.3.1.97 2-[([(1R,3S)-3-[(1-benzofuran-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Leishmania major
2.3.1.97 2-[([(1R,3S)-3-[(1-benzofuran-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Plasmodium falciparum
2.3.1.97 2-[([(1R,3S)-3-[(1-benzofuran-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Trypanosoma brucei
2.3.1.97 2-[([(1R,3S)-3-[(1-benzofuran-6-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Leishmania major
2.3.1.97 2-[([(1R,3S)-3-[(1-benzofuran-6-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Plasmodium falciparum
2.3.1.97 2-[([(1R,3S)-3-[(1-benzofuran-6-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Trypanosoma brucei
2.3.1.97 2-[([(1R,3S)-3-[(1H-indol-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Leishmania major
2.3.1.97 2-[([(1R,3S)-3-[(1H-indol-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Plasmodium falciparum
2.3.1.97 2-[([(1R,3S)-3-[(1H-indol-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide
-
 Trypanosoma brucei
2.3.1.97 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)
-
 Leishmania major
2.3.1.97 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)
-
 Plasmodium falciparum
2.3.1.97 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)
-
 Trypanosoma brucei
2.3.1.97 4-(4,5-dihydroxy-9-methyl-3-oxo-1,3,3a,4,9,9a-hexahydronaphtho[2,3-c]furan-1-yl)-2,5-dihydroxybenzamide
-
 Leishmania major
2.3.1.97 4-(4,5-dihydroxy-9-methyl-3-oxo-1,3,3a,4,9,9a-hexahydronaphtho[2,3-c]furan-1-yl)-2,5-dihydroxybenzamide
-
 Plasmodium falciparum
2.3.1.97 4-(4,5-dihydroxy-9-methyl-3-oxo-1,3,3a,4,9,9a-hexahydronaphtho[2,3-c]furan-1-yl)-2,5-dihydroxybenzamide
-
 Trypanosoma brucei
2.3.1.97 cis-4-[(naphthalen-2-ylmethyl)amino]-N-(6-pyridin-2-yl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
-
 Leishmania major
2.3.1.97 cis-4-[(naphthalen-2-ylmethyl)amino]-N-(6-pyridin-2-yl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
-
 Plasmodium falciparum
2.3.1.97 cis-4-[(naphthalen-2-ylmethyl)amino]-N-(6-pyridin-2-yl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
-
 Trypanosoma brucei
2.3.1.97 cis-N-(6-fluoro-1,3-benzothiazol-2-yl)-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
-
 Leishmania major
2.3.1.97 cis-N-(6-fluoro-1,3-benzothiazol-2-yl)-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
2.3.1.97 cis-N-(6-fluoro-1,3-benzothiazol-2-yl)-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
-
 Trypanosoma brucei
2.3.1.97 cis-N-1,3-benzothiazol-2-yl-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
-
 Leishmania major
2.3.1.97 cis-N-1,3-benzothiazol-2-yl-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
-
 Plasmodium falciparum
2.3.1.97 cis-N-1,3-benzothiazol-2-yl-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
-
 Trypanosoma brucei
2.3.1.97 additional information binding mode, structure-activity relationship and selectivity of inhibitors, overview. The enzyme is a target for rational inhibitor design, modelling of inhibitor docking, overview Leishmania major
2.3.1.97 additional information binding mode, structure-activity relationship and selectivity of inhibitors, overview. The enzyme is a target for rational inhibitor design, modelling of inhibitor docking, overview Plasmodium falciparum
2.3.1.97 additional information binding mode, structure-activity relationship and selectivity of inhibitors, overview. The enzyme is a target for rational inhibitor design, modelling of inhibitor docking, overview Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.97 cytosol
-
 Trypanosoma brucei 5829
-
2.3.1.97 cytosol
-
 Leishmania major 5829
-
2.3.1.97 cytosol
-
 Plasmodium falciparum 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 Leishmania major Q9GPZ4
-
-
2.3.1.97 Plasmodium falciparum Q9U419
-
-
2.3.1.97 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 additional information active site structure, overview Trypanosoma brucei ?
-
 ?
2.3.1.97 additional information active site structure, overview Leishmania major ?
-
 ?
2.3.1.97 additional information active site structure, overview Plasmodium falciparum ?
-
 ?
2.3.1.97 tetradecanoyl-CoA + glycylpeptide i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of a number of eukaryotic cellular and viral proteins Trypanosoma brucei CoA + N-tetradecanoyl-glycylpeptide
-
 ?
2.3.1.97 tetradecanoyl-CoA + glycylpeptide i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of a number of eukaryotic cellular and viral proteins Leishmania major CoA + N-tetradecanoyl-glycylpeptide
-
 ?
2.3.1.97 tetradecanoyl-CoA + glycylpeptide i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of a number of eukaryotic cellular and viral proteins Plasmodium falciparum CoA + N-tetradecanoyl-glycylpeptide
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.97 More three-dimensional model formation using the cyrstal structure and homology modeling method, and energy minimization and molecular dynamics simulations Trypanosoma brucei
2.3.1.97 More three-dimensional model formation using the cyrstal structure and homology modeling method, and energy minimization and molecular dynamics simulations Leishmania major
2.3.1.97 More three-dimensional model formation using the cyrstal structure and homology modeling method, and energy minimization and molecular dynamics simulations Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 myristoyl-CoA:protein N-myristoyltransferase
-
 Trypanosoma brucei
2.3.1.97 myristoyl-CoA:protein N-myristoyltransferase
-
 Leishmania major
2.3.1.97 myristoyl-CoA:protein N-myristoyltransferase
-
 Plasmodium falciparum
2.3.1.97 N-myristoyltransferase
-
 Trypanosoma brucei
2.3.1.97 N-myristoyltransferase
-
 Leishmania major
2.3.1.97 N-myristoyltransferase
-
 Plasmodium falciparum
2.3.1.97 NMT
-
 Trypanosoma brucei
2.3.1.97 NMT
-
 Leishmania major
2.3.1.97 NMT
-
 Plasmodium falciparum