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Literature summary extracted from

  • Aparoy, P.; Reddy, R.N.; Guruprasad, L.; Reddy, M.R.; Reddanna, P.
    Homology modeling of 5-lipoxygenase and hints for better inhibitor design (2008), J. Comput. Aided Mol. Des., 22, 611-619.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 1-(benzyloxy)hept-2-yn-4-ol forms three hydrogen bonds with 5-lipoxygenase Solanum tuberosum
1.13.11.34 1-[(4methylbenzyl)oxy]hept-2-yn-4-ol is more potent than 1-(benzyloxy)hept-2-yn-4-ol to 5-lipoxygenase Solanum tuberosum
1.13.11.34 additional information [(hept-2-yn-1-ylsulfanyl)methyl]benzene is no inhibitor, there are no strong interactions to stabilize the compound in the 5-lipoxygenase active site Solanum tuberosum
1.13.11.34 nordihydroguaiaretic acid is more potent inhibitor of 5-lipoxygenase than 1-(benzyloxy)hept-2-yn-4-ol Solanum tuberosum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Fe2+ Asn720 is present in the fifth coordination position of iron Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Solanum tuberosum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 additional information 5-lipoxygenase has a two-domain structure, the small N-terminal beta-barrel domain and a larger catalytic domain containing a single atom of non-heme iron coordinating with His525, His530, His716 and Ile864 Solanum tuberosum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Solanum tuberosum
1.13.11.34 5-LOX
-
 Solanum tuberosum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.0015
-
-
 Solanum tuberosum nordihydroguaiaretic acid
1.13.11.34 0.045
-
-
 Solanum tuberosum 1-[(4methylbenzyl)oxy]hept-2-yn-4-ol
1.13.11.34 0.76
-
-
 Solanum tuberosum 1-(benzyloxy)hept-2-yn-4-ol