Literature summary extracted from

Tomkova, J.; Friedecky, D.; Polynkova, A.; Adam, T.
Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes (2009), J. Chromatogr. B, 877, 1943-1945.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.67	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.67	erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.67	S-adenosyl-L-methionine + 6-mercaptopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + 6-methylmercaptopurine	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.67	thiopurine methyl transferase	-	Homo sapiens
2.1.1.67	TPMT	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
2.1.1.67	Homo sapiens	decreased activity of TPMT is associated with hematopoietic toxicity after administration of standard doses of 6- mercaptopurine or azathioprine	down

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Release 2023.1 (January 2023)