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Literature summary extracted from

  • Stenta, M.; Calvaresi, M.; Altoè, P.; Spinelli, D.; Garavelli, M.; Galeazzi, R.; Bottoni, A.
    Catalytic mechanism of diaminopimelate epimerase: A QM/MM investigation (2009), J. Chem. Theory Comput., 5, 1915-1930.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.1.1.7 drug development enzyme represents a promising target for rational drug design aimed to develop new selective antibacterial therapeutic agents Haemophilus influenzae

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.1.7 DL-aziridino-diaminopimelate product-like inhibitor, inhibitor mimics the natural substrate, the methylene carbon of the aziridine ring of the 2 diastereomeric inhibitors is covalently bonded to the sulfur atom of Cys73 or Cys217 after the nucleophilic attack of the sulfur on the aziridine ring that irreversibly inhibits the enzyme Haemophilus influenzae
5.1.1.7 LL-aziridino-diaminopimelate reactant-like inhibitor, inhibitor mimics the natural substrate, the methylene carbon of the aziridine ring of the 2 diastereomeric inhibitors is covalently bonded to the sulfur atom of Cys73 or Cys217 after the nucleophilic attack of the sulfur on the aziridine ring that irreversibly inhibits the enzyme Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.7 LL-2,6-diaminoheptanedioate Haemophilus influenzae stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) meso-diaminopimelate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.7 Haemophilus influenzae P44859
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.7 LL-2,6-diaminoheptanedioate stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) Haemophilus influenzae meso-diaminopimelate
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.1.1.7 diaminopimelate epimerase
-
 Haemophilus influenzae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.1.1.7 128
-
 LL-2,6-Diaminoheptanedioate forward reaction Haemophilus influenzae

General Information

EC Number General Information Comment Organism
5.1.1.7 physiological function enzyme belongs to the group of isomerases which are capable of inverting the absolute configuration of a carbon atom in substrates containing one (racemases) or more stereocenters Haemophilus influenzae