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Literature summary extracted from

  • Andrade, C.H.; Pasqualoto, K.F.; Ferreira, E.I.; Hopfinger, A.J.
    Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors (2009), J. Chem. Inf. Model., 49, 1070-1078.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.9 1,3-bis[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea
-
 Mycobacterium tuberculosis
2.7.4.9 1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[(2S,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Mycobacterium tuberculosis
2.7.4.9 1-[(2S,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Mycobacterium tuberculosis
2.7.4.9 1-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]-3-phenylthiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]thiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]urea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methoxyphenyl)thiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methylphenyl)thiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-pyridin-3-ylthiourea
-
 Mycobacterium tuberculosis
2.7.4.9 1-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]-3-phenylthiourea
-
 Mycobacterium tuberculosis
2.7.4.9 3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
-
 Mycobacterium tuberculosis
2.7.4.9 3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
-
 Mycobacterium tuberculosis
2.7.4.9 3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-([[4-chloro-3-(trifluoromethyl)benzyl]carbamothioyl]amino)-5'-deoxythymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-([[2-(3,4-dichlorophenyl)ethyl]carbamothioyl]amino)thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-[[(2-phenylethyl)carbamothioyl]amino]thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-[[(3,4-dichlorophenyl)carbamoyl]amino]thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-[[(4-morpholin-4-ylphenyl)carbamothioyl]amino]thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-deoxy-5'-[[(phenylcarbonyl)carbamothioyl]amino]thymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-[(benzylcarbamothioyl)amino]-5'-deoxythymidine
-
 Mycobacterium tuberculosis
2.7.4.9 5'-[([[9-(2-carboxyphenyl)-3-oxo-2,3-dihydro-1H-xanthen-6-yl]oxy]carbamothioyl)amino]-5'-deoxythymidine
-
 Mycobacterium tuberculosis
2.7.4.9 N-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]benzamide
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.9 Mycobacterium tuberculosis P9WKE1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.9 ATP + dTMP
-
 Mycobacterium tuberculosis ADP + dTDP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.9 thymidine monophosphate kinase
-
 Mycobacterium tuberculosis
2.7.4.9 TMPK
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.9 ATP
-
 Mycobacterium tuberculosis