Literature summary extracted from

Lee, W.H.; Liu, F.H.; Lin, J.Y.; Huang, S.Y.; Lin, H.; Liao, W.J.; Huang, H.M.
JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis (2009), J. Cell. Biochem., 106, 929-936.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.10.2	interleukin 5	activates Janus kinases JAK1 and JAK2	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.10.2	expressed in Ba/F3 cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.10.2	AG490	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.10.2	ATP + a [protein]-L-tyrosine	Homo sapiens	-	ADP + a [protein]-L-tyrosine phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.2	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.10.2	ATP + a [protein]-L-tyrosine	-	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.10.2	Jak1	-	Homo sapiens
2.7.10.2	JAK2	-	Homo sapiens
2.7.10.2	Janus kinase	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.10.2	ATP	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.7.10.2	physiological function	JAK1 and JAK2 activate c-Myc promoter in interleukin 5 signaling	Homo sapiens

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Release 2023.1 (January 2023)