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Literature summary extracted from

  • Gan, Q.; Li, T.; Hu, B.; Lian, M.; Zheng, X.
    HSCARG inhibits activation of NF-kappaB by interacting with IkappaB kinase-beta (2009), J. Cell Sci., 122, 4081-4088.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.10 IKKalpha, IKKbeta and IKKgamma, cloned into pRK-FLAG or pRK-HA, are used, IKKbeta fragments, aa1-398, aa399-576, aa577-756, are inserted into the vector pRK-FLAG Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 protein HSCARG or NMRAL1, NmrA-like family domain-containing protein 1, inhibits the phosphorylation of IKKbeta Homo sapiens
2.7.11.10 shRNA
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.10 nuclear and cytoplasmic extracts are prepared Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 HEK-293T cell
-
 Homo sapiens
-
2.7.11.10 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase-beta
-
 Homo sapiens
2.7.11.10 IKKbeta
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Homo sapiens