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Literature summary extracted from

  • Cai, Y.; Jin, J.; Swanson, S.K.; Cole, M.D.; Choi, S.H.; Florens, L.; Washburn, M.P.; Conaway, J.W.; Conaway, R.C.
    Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex (2009), J. Biol. Chem., 285, 4268-4272.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.48 stable overexpression of FLAG-tagged MOF-conbtaining complex subunits in HEK293/FRT or HeLa S3 cells, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleosome
-
Homo sapiens 786
-
2.3.1.48 nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 Homo sapiens MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on Lys16, while NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on Lys5 and Lys8 CoA + acetylhistone H4
-
?
2.3.1.48 additional information Homo sapiens besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
-
MOF
-
2.3.1.48 Homo sapiens Q9H7Z6 catalytic subunit of the male-specific lethal hiostone acetyltransferase complex
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4
-
Homo sapiens CoA + acetylhistone H4
-
?
2.3.1.48 acetyl-CoA + histone H4 MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on Lys16, while NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on Lys5 and Lys8 Homo sapiens CoA + acetylhistone H4
-
?
2.3.1.48 additional information besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity Homo sapiens ?
-
?
2.3.1.48 additional information no activity with histones H3, H2A and H2B by recombinant MOF in HeLa nucleosomes Homo sapiens ?
-
?
2.3.1.48 additional information assembly of the enzyme into male-specific lethal, MSL, or non-specific lethal, NSL, complexes controls its substrate specificity. Although MSL-associated enzyme acetylates nucleosomal histone H4 almost exclusively on lysine 16, NSL-associated enzyme exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on lysines 5 and 8 Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.48 More besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, subunit composition of the NSL complex, overview. Two of its subunits,WD repeat domain 5, WDR5, and host cell factor 1, HCF1, are shared with members of the MLL/SET family of histone H3 lysine 4 methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex Homo sapiens
2.3.1.48 More enzyme is the catalytic subunit of the male-specific lethal hiostone acetyltransferase complex NSL, which is composed of nine subunits. Two of its subunits,WD-repeat domain WDR5 and host cell factor HCF1, are shared with members of the MLL/SET family of histone H3 lysine 4 methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. Assembly of the enzyme into MSL or NSL complexes controls its substrate specificity Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Mof
-
Homo sapiens
2.3.1.48 More MOF is a member of the MYST, i.e. Moz-Ybf2/Sas3-Sas2-Tip60, family of histone acetyltransferases, HATs Homo sapiens
2.3.1.48 MYST1
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.48 acetyl-CoA
-
Homo sapiens