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Literature summary extracted from

  • Lewis, E.M.; Sergeant, S.; Ledford, B.; Stull, N.; Dinauer, M.C.; McPhail, L.C.
    Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding (2010), J. Biol. Chem., 285, 2959-2967.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 additional information PKC is activated by the addition of 0.03 mg/ml 10:0 1,2-didecanoyl-sn-glycero-3-phosphate, 0.01 mg/ml 1-oleoyl-2-acetoyl-sn-glycerol, and 0.6 mM CaCl2 (no CaCl2 for isoform PKC-delta) for 30 min at 37°C Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 CHO-91-47-67 cell
-
 Cricetulus griseus
-
2.7.11.13 CHO-K1 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + mutant protein p22phox(P156Q)
-
 Cricetulus griseus ADP + phosphorylated mutant protein p22phox(P156Q)
-
 ?
2.7.11.13 ATP + mutant protein p22phox(T132A)
-
 Cricetulus griseus ADP + phosphorylated mutant protein p22phox(T132A)
-
 ?
2.7.11.13 ATP + NADPH oxidase
-
 Cricetulus griseus ADP + phosphorylated NADPH oxidase
-
 ?
2.7.11.13 ATP + protein p22phox threonine 147 of protein p22phox is phosphorylated by PKC-alpha and PKC-delta isoforms in vitro Cricetulus griseus ADP + phosphorylated protein p22phox
-
 ?
2.7.11.13 additional information no phosphorylation of the mutant protein p22phox (T147A) by PKC-alpha or PKC-delta in vitro Cricetulus griseus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC-alpha isoform Cricetulus griseus
2.7.11.13 PKC-delta isoform Cricetulus griseus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.13 ATP
-
 Cricetulus griseus