EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | cardiolipin | enzymatic activity is induced 23fold at 0.1 mM | Mus musculus | |
3.1.4.12 | additional information | phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol have minimal effects on MA-nSMase activity | Mus musculus | |
3.1.4.12 | phosphatidylglycerol | enzymatic activity is induced 8fold at 0.1 mM | Mus musculus | |
3.1.4.12 | phosphatidylserine | enzymatic activity is induced 15fold at 0.1 mM | Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.4.12 | expressed in HEK-293 cells and MCF-7 cells | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.12 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
3.1.4.12 | mitochondrion | - |
Mus musculus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | Mg2+ | absolute requirement for cations such as Mg2+ and Mn2+ | Mus musculus | |
3.1.4.12 | Mn2+ | absolute requirement for cations such as Mg2+ and Mn2+ | Mus musculus | |
3.1.4.12 | additional information | Ca2+, Co2+, Fe2+, or Zn2+ do not support MA-nSMase activity | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 50000 | - |
SDS-PAGE | Mus musculus |
3.1.4.12 | 53870 | - |
calculated from amino acid sequence | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Mus musculus | D6MZJ6 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | brain | - |
Mus musculus | - |
3.1.4.12 | epididymis | - |
Mus musculus | - |
3.1.4.12 | pancreas | - |
Mus musculus | - |
3.1.4.12 | testis | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | - |
Mus musculus | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | MA-nSMase | - |
Mus musculus |
3.1.4.12 | mitochondrial-associated neutral sphingomyelinase | - |
Mus musculus |
3.1.4.12 | SMPD | - |
Mus musculus |
3.1.4.12 | sphingomyelin phosphodiesterase 5 | - |
Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 7.5 | - |
the MA-nSMase has no acid SMase activity | Mus musculus |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
3.1.4.12 | Mus musculus | calculated from amino acid sequence | - |
8.6 |